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Coagulation Defects
Coagulation Defects
by Alike Medical Team ∙ Updated on June 13, 2023
Additional names
This group contains additional names: - Congenital Factor XI Disorder - Congenital Factor VIII Disorder - Antiphospholipid Antibody Disorder - Congenital Factor IX Disorder - Defibrination Syndrome
General
Coagulation is a process in which blood changes from a liquid to a gel, in order to form a clot and hopefully stop bleeding. This process begins almost instantly after a blood vessel has been damaged. The coagulation cascade is a very complex process that involves many different proteins and results in the deposition and maturation of fibrin, which strengthens the platelet plug formed by platelets.Our body's ability to stop bleeding depends on our platelets, coagulation factors and vascular factors. Each of these proteins, also known as coagulation factors, can be missing or damaged. As a result, the coagulation process may be harmed and this can result in excessive bleeding. Many of these disorders, such as hemophilia, are inherited.
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Learn from others who are experiencing Coagulation Defects.
Signs & symptoms
Symptoms depend on the coagulation factor missing and how much is missing. For example, a specific factor can be totally missing or only 30% missing. The symptoms are in accordance with the deficiency. They may include excessive bleeding from trauma or invasive procedures, heavy menstrual bleeding, joint bleeding, nasal bleeding, gum bleeding.
Diagnosis
Since many of these disorders are inherited, it is important to thoroughly go through *family history*. *The patient's bleeding history* should be carefully examined in events such as childbirth, dental procedures, surgeries etc. Blood tests- *Blood clotting tests*- Prothrombin (PT), and partial thromboplastin time (PTT). These tests determine your clot formation ability. Usually, when there is a coagulation defect, the clotting time will be prolonged. *Factor activity tests*- If PT/ PTT is abnormal, and a coagulation defect is suspected, the doctor will test for specific factor levels in your blood.
Treatment
The treatment depends on the type of disorder and the clinical state. If acute bleeding is present, plasma or other plasma concentrates can be given. In the chronic state, some disorders can be treated with an artificially produced coagulation factor. Other disorders are treated with other means such as medications or blood products. It is important to consult with your doctor before any invasive procedure in order to avoid lifethreatning bleeding.
Note
☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.
National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention
☝ All information has been reviewed by certified physicians from Alike
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Should I have stayed on Xarelto?
I talk Xarelto and will for life. I didn't have urine issues, but did nearly bleed to death from menstruation and had to have a hysterectomy. I now sometimes have small amounts of blood in my stool from the Xarelto, but have been told "some bleeding" is normal since it's a blood thinner and nothing to worry about. I'd talk to your doctor and see if that's your case or if maybe something else is going on or if you need a different med/dose. (I had a clot from my ankle to my groin & bilateral saddle PEs at the same time. Found out after that I have a **blood clotting disorder**).
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