Understanding Mantle Cell Lymphoma: Causes, Symptoms, and Management

What is it?

Mantle Cell Lymphoma is a rare and aggressive type of non-Hodgkin lymphoma, characterized by the uncontrolled growth of B-cells in the lymphatic system. It's named after its origin in the "mantle zone" of the lymph nodes. It comprises roughly 5% of all non-Hodgkin lymphoma cases and typically occurs in older adults.
MCL typically affects older adults and is more common in men. The cause remains unclear, but genetic mutations play a role. It's known for its aggressive nature and tendency to spread quickly.

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Signs & symptoms

Common symptoms include swollen lymph nodes, fatigue, weight loss, and night sweats. Symptoms may be subtle at first, gradually worsening over time.

Diagnosis

Diagnosis involves lymph node biopsies, blood tests, and imaging studies. Identifying the specific genetic changes in MCL cells is crucial for diagnosis and treatment planning.

Treatment

Treatment for mantle cell leukemia often involves a combination of chemotherapy, immunotherapy, and, in some cases, stem cell transplantation. Newer treatments focus on targeting specific aspects of MCL cells. Despite the challenges posed by its aggressiveness, advancements in targeted therapies and a better understanding of the disease's biology offer hope for improved management and outcomes for individuals diagnosed with mantle cell leukemia.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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Source of Information - We analyze big data of more than 23 million patients de-identified medical records from the following sources:

National Institution of Health ∙ World Health Organization ∙ University of Illinois hospital