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Aspirin Exacerbated Respiratory Disease
Aspirin Exacerbated Respiratory Disease
by Alike Medical Team ∙ Updated on June 13, 2023
Additional names
This group contains additional names: - Samter's Triad - Aspirin-Exacerbated Respiratory Tract Disease - AERD
General
Aspirin Exacerbated Respiratory Disease (AERD), also known as Samter's Triad or Aspirin-Exacerbated Respiratory Tract Disease (AERD), is a condition characterized by the combination of asthma, nasal polyps, and respiratory reactions to non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin.
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Signs & symptoms
- Asthma: Persistent cough, wheezing, shortness of breath, chest tightness, and respiratory distress. - Nasal polyps: Noncancerous growths in the nasal passages that can cause congestion, runny nose, postnasal drip, and reduced sense of smell. - Aspirin/NSAID sensitivity: Taking aspirin or NSAIDs can trigger respiratory symptoms such as asthma attacks, nasal congestion, and nasal polyp inflammation.
Diagnosis
- Medical history: The doctor will ask about your symptoms, including any respiratory reactions to aspirin or NSAIDs. - Physical examination: The doctor may check for nasal polyps or signs of asthma. - Aspirin challenge: This is a controlled test where a small dose of aspirin is given under medical supervision to monitor for any adverse reactions. - Other tests: Lung function tests, allergy testing, and imaging studies may be performed to evaluate the severity and extent of the disease.
Treatment
- Medications: AERD is typically managed with a combination of medications, including: - Corticosteroids: Nasal sprays or oral medications to reduce nasal polyps and inflammation. - Leukotriene modifiers: Medications that help alleviate asthma symptoms and reduce nasal polyp formation. - Mast cell stabilizers: Nasal sprays or eye drops that help prevent allergic reactions. - Aspirin desensitization: Under medical supervision, a process of gradually increasing doses of aspirin is administered to increase tolerance and reduce reactions. - Surgical intervention: In severe cases, where medical treatment is insufficient, surgery may be necessary to remove nasal polyps. - Allergy management: Avoidance of aspirin and NSAIDs is recommended, and management of other allergies may help improve symptoms.
Note
☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.
National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention
☝ All information has been reviewed by certified physicians from Alike
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