What is it?

Factor V Leiden is one of the clotting factors in our blood. Mutation in one of the factor’s genes may cause hypercoagulability, causing clots mainly in the lungs and the legs, although most people will never develop blood clots. Women who have these mutations may develop blood clots under estrogen therapy or during pregnancy.

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Primary hypercoagulable state.

Additional names

This group contains additional names:
- Factor 5 Leiden mutation

Signs & symptoms

factor V Leiden mutation symptoms may include deep vein thrombosis (pain, swelling, redness and warmth) due to blood clot in the leg. This blood clot may travel through the bloodstream to the lungs and cause shortness of breath, chest pain, cough and rapid heartbeat- this could be life threatening.


Diagnosis is based upon findings from medical history, family history and physical examination. Further evaluation may include a blood test.


Treatment may include blood thinners for those who experienced blood clots, leg wraps, and compression stockings.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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