What is it?

Common variable immunodeficiency (CVID) is a disorder characterized by low levels of proteins that help the body fight infections. People who have CVID tend to get recurrent infections such as ear, sinuses and respiratory infections. CVID could be either congenital or acquired, but the reason is unknown. Only in 10% a genetic mutation was found. People diagnosed with CVID also tend to suffer from malignancies.

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Common variable immunodeficiency.

Additional names

This group contains additional names:
- Primary immune deficiency disease

Signs & symptoms

CVID symptoms may include recurrent infections of the lungs, sinuses and ears. Some could also suffer from inflammation of the gastrointestinal tract. The accumulation of lymph nodes may cause enlarged lymph nodes or enlarged spleen.


Diagnosis is suspected in people who suffer from recurrent infections and is based upon findings from medical history and physical examination. People usually get diagnosed between the age 20-30


Treatment may include immunoglobulin replacement therapy (IRT), and antibiotics for infections.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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