What is it?

Chronic multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is an autoimmune disease - a disorder in which the autoimmune system attacks itself. CRMO is a rare disorder that causes inflammation of the bone. CRMO usually occurs in children around the age of nine or 10 and occurs more frequently in girls than in boys.

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Signs & symptoms

The most common symptom of CRMO is pain in the bones. Other symptoms may include:
- Swelling in the joints
- Fever in some cases


To diagnose CRMO, a pediatric rheumatologist will first exclude the possibility of an underlying disease causing your child’s symptoms. Your healthcare provider will conduct a physical exam and may order some tests, which may include:
- X-ray - looking for bone damage
- Magnetic resonance imaging (MRI) - detects bone lesions in higher definitions
- Blood tests - can show elevated levels of inflammation
Bone biopsy rules out infection or cancer, and shows inflammation


There is no cure for CRMO. The main goal of treatment is to reduce pain, prevent bone growths and deformities, and improve your child's quality of life.
Some medications may include:
- Non-steroidal anti-inflammatory medications (NSAID)
- Steroids
- Biological agents - adalimumab, anakinra, and infliximab. these medications are given in more severe cases.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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