What is it?

Tumor lysis syndrome (TLS) is a condition that may occur to people suffering from malignancy when a large number of cancer cells die in a short period and release their content into the bloodstream. These contents include high levels of uric acid, potassium and phosphorus. Due to high levels of phosphorus binding calcium in the blood, low levels of calcium are seen. People who are at greater risk for TLS are those with a large tumor burden such as leukemia, lymphoma as tumors that are highly responsive to treatment.

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Signs & symptoms

Symptoms may include nausea, vomiting, lack of appetite, fatigue, dark urine, flank pain, numbness, seizures, hallucinations, muscle cramps and spasms, and palpitations.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation includes blood tests.


Treatment includes intravenous fluids, allopurinol, and rasburicase as well as correction of electrolyte imbalance.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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