Understanding Transient acantholytic dermatosis: Causes, Symptoms, and Management

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Transient acantholytic dermatosis

by Alike Medical Team ∙ Updated on June 13, 2023

Additional names

This group contains additional names: - Grovers disease

General

Transient acantholytic dermatosis, also known as Grover disease, is a common acquired itchy truncal rash characterised by acantholysis on histopathology.

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Signs & symptoms

Transient acantholytic dermatosis often starts quite suddenly. Some (but not all) studies report it is more common in winter than in summer. * The most common sites affected are central back, mid chest, and upper arms. * Lesions are small red, crusted, or eroded papules and vesicles * The rash is typically intensely itchy.

Diagnosis

Transient acantholytic dermatosis is usually diagnosed clinically, but a skin biopsy may be necessary. The pathology of transient acantholytic dermatosis is characteristic, with acantholysis (separated skin cells) with or without dyskeratosis (abnormal rounded skin cells). Spongiotic dermatitis may also be noted. Four histological patterns are recognised, not all of which show the classic acantholytic pattern.

Treatment

There is no curative treatment for transient acantholytic dermatosis, but the following suggestions may relieve the itch and hasten resolution. * Remain cool, as sweating may induce more itchy spots. * Moisturising creams or antipruritic lotions containing menthol and camphor can reduce the desire to scratch. * Apply a topical steroid, if possible as a lotion, to relieve itch.

Note

☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.

National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention

☝ All information has been reviewed by certified physicians from Alike

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