What is it?

Transient acantholytic dermatosis, also known as Grover disease, is a common acquired itchy truncal rash characterised by acantholysis on histopathology.

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Transient acantholytic dermatosis.

Additional names

This group contains additional names:
- Grovers disease

Signs & symptoms

Transient acantholytic dermatosis often starts quite suddenly. Some (but not all) studies report it is more common in winter than in summer.
* The most common sites affected are central back, mid chest, and upper arms.
* Lesions are small red, crusted, or eroded papules and vesicles
* The rash is typically intensely itchy.


Transient acantholytic dermatosis is usually diagnosed clinically, but a skin biopsy may be necessary.
The pathology of transient acantholytic dermatosis is characteristic, with acantholysis (separated skin cells) with or without dyskeratosis (abnormal rounded skin cells). Spongiotic dermatitis may also be noted. Four histological patterns are recognised, not all of which show the classic acantholytic pattern.


There is no curative treatment for transient acantholytic dermatosis, but the following suggestions may relieve the itch and hasten resolution.
* Remain cool, as sweating may induce more itchy spots.
* Moisturising creams or antipruritic lotions containing menthol and camphor can reduce the desire to scratch.
* Apply a topical steroid, if possible as a lotion, to relieve itch.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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