What is it?

Systemic mastocytosis refers to a rare condition which is characterized by accumulation of mast cells in body organs such as the skin, digestive tract and bone marrow. Mast cells may get triggered by alcohol, spicy food, insect bites, medications and release substances that cause a reaction similar to an allergic reaction. There are several types of mastocytosis.

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Signs & symptoms

Symptoms depend on the site of mast cell accumulation and may include flushing, itching, hves, abdominal pain, nausea, vomiting, bleeding disorders, anemia, muscle pain, bone pain, and mood disorders.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include blood tests, urine tests, skin biopsy, imaging tests, biopsy, and genetic testing.


Treatment depends on the type of systemic mastocytosis and the organs affected. Treatment may include avoiding triggers, medications such as antihistamines, steroids, KIT inhibitors, chemotherapy, and stem cell transplant.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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