What is it?

Thrombophilia is a term that refers to a group of medical conditions in which there are too many clotting factors in the blood. The excess clotting factors may induce blood clots. Primary thrombophilias are inherited conditions, which may include Factor V leiden thrombophilia, prothrombin thrombophilia, protein C and S deficiency and Antithrombin III deficiency. In primary thrombophilia there is an increased risk for early event of deep vein thrombosis (DVT).

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Additional names

This group contains additional names:
- Antithrombin III deficiency
- Protein C deficiency
- Protein S deficiency

Signs & symptoms

In many cases, there are no symptoms at all. In other cases, symptoms depend on where the blood clot is formed. For example, a blood clot in the lungs may cause fast breathing, fast heart rate, shortness of breath, painful deep breathing and chest pain.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include blood tests and genetic testing.


Treatment is not always required, but may include blood thinners.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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Frequently asked questions
Is Primary Thrombophilia hereditary?
Can Primary Thrombophilia affect pregnancy?

☝ The content of this answer is based solely on historical posts and comments generated by users on Alike. This tool is not a substitute for professional medical advice, and you should always consult with your physicians before making any changes to your medical care or treatment plan.

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