What is it?

Primary biliary cholangitis is a chronic disease in which the bile ducts in your liver are slowly destroyed. Bile is a fluid made in your liver and stored in your gallbladder. It helps with digestion, with absorbing several vitamins, and with getting rid of toxins, cholesterol, and worn-out red blood cells. Chronic inflammation in the liver may harm the bile ducts, and can lead to bile duct damage, irreversible scarring of liver tissue (cirrhosis) and eventually, liver failure. There is no clear understanding of what is causing PBC. Although many clinicians and researches consider it an autoimmune disease in which the body attacks itself.

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Signs & symptoms

Early symptoms of PBC may include itchy skin (pruritis) and fatigue, while late symptoms may include right upper abdomen pain, dry eyes, spleen swelling, bone, muscle of joint tissue pain, yellow pale skin (jaundice), and more.


After asking you about your health history and complaints and performing a physical examination, your doctor may perform a few blood and imaging tests to get to the right diagnosis. The blood tests may consist of liver enzymes like AST, ALT bile duct enzymes like GGT, and antibody tests for autoimmune diseases like AMA. Imaging tests can include ultrasound, fibroscan, Magnetic resonance cholangiopancreatography (MRCP), and Magnetic resonance elastography (MRE). If diagnosis is still uncertain, your doctor may choose to perform a liver biopsy.


There is no cure for PBC, but the medications are available of slowing the disease progression. Ursodeoxycholic acid (UDCA) - helps to move the bile through your liver, Obeticholic acid (Ocaliva), and liver transplant.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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