What is it?

Postcholecystectomy syndrome refers to abdominal symptoms present after a surgery to remove the gallbladder. These symptoms may be either transient, persistent or lifelong. Most commonly, it is caused actually by extrabiliary disorders, such as pancreatitis and its complications. Biliary causes may include bile salt induced diarrhea, retained calculi, bile leak, biliary strictures and dyskinesia of the sphincter of Oddi. There could also be psychiatric and neurologic disorders that explain the symptoms.

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Signs & symptoms

Symptoms may include dyspepsia, fatty food intolerance, jaundice, nausea, vomiting, flatulence, bloating, diarrhea, and persistent pain in the right upper quadrant.


Diagnosis of postcholecystectomy syndrome is made when there is a history of a cholecystectomy and the presence of abdominal symptoms. Other results may include ultrasound, blood tests, cholangiography, and endoscopic retrograde cholangiopancreatography (ERCP) .


It is usually recommended to restrict fat in the diet. Sometimes, supplements such as enzyme preparations, antispasmodics, and sometimes cholagogue which promotes discharge of bile from the system. Treatment depends on the underlying cause for the symptoms buy may also include ursodeoxycholic acid for bile microlithiasis, bile acid sequestrant therapy for bile acid diarrhea

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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