What is it?

Spleen neoplasm, or spleen cancer, is pretty unusual and is very rare. Usually, it happens when cancer from another part of the body spreads to the spleen, such as lymphomas or leukemias, as the spleen is an organ belonging to the lymphatic system. Sometimes, cancers like breast, lung, stomach, pancreas, liver or colon may be the source of the spread. A neoplasm that develops in the spleen is called splenic marginal zone lymphoma, which is very rare.

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Malignant Neoplasm of Spleen.

Additional names

This group contains additional names:
- Angiosarcoma of spleen
- Cancer of the spleen
- Fibrosarcoma of spleen
- Malignant tumor of spleen
- Splenic cancer

Signs & symptoms

Symptoms of spleen malignancy may include swollen lymph nodes, recurrent infections, unintended weight loss, fever, night sweats, joint and bone pain, anemia, fatigue, frequent bruising, and abdominal pain.


Spleen neoplasm is diagnosed based on findings from physical exam, medical history, blood tests, bone- marrow biopsy and imaging such as CT, PET-CT or MRI.


Treatment of spleen cancer depends on the specific disease involved, age, cancer’s stage of development and more. Treatment options may include surgery, which can also be a diagnostic tool, radiation, stem cell transplantation, immunotherapy, targeted therapy or surveillance.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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