What is it?

Mad Hatter’s Disease, also known as Mad Hatter's Syndrome, is a condition caused by prolonged exposure to mercury, typically from occupational exposure in industries such as hat making, dental work, and gold mining. The condition is named after the character in Lewis Carroll's "Alice's Adventures in Wonderland" because hat makers in the 19th century were known to use mercury in their work.

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Additional names

This group contains additional names:
- Mad Hatter's Syndrome
- Mercury poisoning

Signs & symptoms

Symptoms of Mad Hatter's Disease include tremors, personality changes, irritability, memory loss, difficulty with speech, hearing and vision problems, and sensory impairment. These symptoms can occur gradually over time with prolonged exposure to mercury.


Diagnosis of Mad Hatter's Disease is made based on a physical examination, medical history, and laboratory tests to measure levels of mercury in the body. Imaging studies, such as CT scans and MRIs, may also be used to evaluate the extent of damage caused by mercury exposure.


Treatment for Mad Hatter's Disease involves reducing or eliminating exposure to mercury, which may include changes in occupation or work environment. Chelation therapy, a medical treatment that involves the use of medications to remove heavy metals from the body, may also be used in some cases. The goal of treatment is to slow or stop the progression of symptoms and prevent further damage to the nervous system.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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