What is it?

Langerhans Cell Histiocytosis (LCH) is a rare disorder of the immune system in which excess numbers of a type of immune cell called Langerhans cells accumulate in various tissues of the body. These cells are normally found in the skin and mucous membranes and play a role in the body's defense against infection.

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Additional names

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Signs & symptoms

Symptoms of LCH can vary depending on which part of the body is affected, but may include:

- Skin rash or sores
- Swollen lymph nodes
- Bone pain or swelling
- Fatigue
- Weight loss
- Fever
- Difficulty breathing
- Abdominal pain
- Increased thirst and urination


LCH can be challenging to diagnose because it can present with a wide range of symptoms and can affect multiple organs. Diagnostic tests may include:

- Biopsy of affected tissue to examine Langerhans cells under a microscope
- Blood tests to look for certain markers of LCH
- Imaging tests such as X-rays, CT scans or MRI scans to look for abnormalities in the bones, lungs or other organs
- Pulmonary function tests to assess lung function


Treatment for LCH depends on the extent and severity of the disease. In some cases, the disease may go away on its own without treatment. In other cases, treatment may involve medications such as corticosteroids or chemotherapy to suppress the immune system and reduce the number of abnormal cells. Surgery may also be necessary in some cases to remove affected tissue.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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