What is it?

Pulmonary Interstitial Emphysema (PIE) refers to a rare condition which is characterized by a collection of ais and gases outside the lung alveoli. These collections put pressure on the lung tissue and may cause damage to it. It is more common in premature newborns though it may occur in adults as well. PIE may be categorized into acute, chronic, localized and diffuse groups. In adults, it may be a result of a complication or a lung disease or an intervention done on the lungs.

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Signs & symptoms

Symptoms may include grunting, wheezing, breathing diffulties, paleness, peripheral cyanosis, and trouble eating and gaining weight.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include imaging tests of the lungs.


In premature babies, it is important to try and reduce the risk for PIE by treating thme with surfactant, and positioning the babies in lateral decubitus. Other treatments may include ventilation, steroids, and lovbectomy.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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