What is it?

Angioneurotic Edema is a rare disorder causing angioedema. In this disorder, the person lacks C1 esterase inhibitor, which is a protein that prevents swelling. People who have angioneurotic edema may suffer from recurrent attacks of swollen tissues, including swelling of the voice box. Also, abdominal pain is common. The disorder can be either hereditary or acquired.

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Signs & symptoms

Symptoms of angioneurotic edema vary from patient to patient but may include recurrent spontaneous non itching edema, lasting from 3-5 days. Triggers may include trauma,stress, and changes in the female’s hormonal cycle. Episodes of abdominal pain mimicking a surgical emergency may happen as well.


Angioneurotic Edema is suspected when there are recurrent events of angioedema. After medical history and physical examination, blood tests may indicate low blood levels of C1 esterase inhibitor.


Treatment for Angioneurotic edema may include a replacement therapy for C1 esterase inhibitor.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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