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Hereditary Alpha tryptasemia
Hereditary Alpha tryptasemia
by Alike Medical Team ∙ Updated on June 13, 2023
General
Hereditary Alpha tryptasemia (HaT) is a genetic trait caused by an extra copy of the TPSAB1 gene, which is responsible for an extra alpha -tryptase, leading to high tryptase levels in the blood. It is quite a common trait. Tryptase is a chemical produced by immune cells called mast cells during allergic reactions and is known to be higher in patients with HaT. It is not fully understood yet if having HaT is really linked or not to mast cell activation and anaphylaxis.
14 people with Hereditary Alpha tryptasemia are on Alike.
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Signs & symptoms
Symptoms may include increased frequency and severity of anaphylaxis events due to insect bites or idiopathic anaphylaxis, when the trigger is not found. Some other symptoms which may be linked are skin flushing, hives, itching, allergy to bee stings, chronic pain or skeletal abnormalities.
Diagnosis
Many of the people with Hereditary Alpha tryptasemia are not diagnosed due to lack of symptoms. Diagnosis is done by genetic testing.
Treatment
Most people with HaT will not require any treatment. Omalizumab and antihistamines may help for those who experience symptoms.
Note
☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.
National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention
☝ All information has been reviewed by certified physicians from Alike
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