Hereditary Alpha tryptasemia
What is it?
Hereditary Alpha tryptasemia (HaT) is a genetic trait caused by an extra copy of the TPSAB1 gene, which is responsible for an extra alpha -tryptase, leading to high tryptase levels in the blood. It is quite a common trait. Tryptase is a chemical produced by immune cells called mast cells during allergic reactions and is known to be higher in patients with HaT. It is not fully understood yet if having HaT is really linked or not to mast cell activation and anaphylaxis.
14 Alikes with Hereditary Alpha tryptasemia
Learn from others
who are experiencing
Hereditary Alpha tryptasemia.
Signs & symptoms
Symptoms may include increased frequency and severity of anaphylaxis events due to insect bites or idiopathic anaphylaxis, when the trigger is not found. Some other symptoms which may be linked are skin flushing, hives, itching, allergy to bee stings, chronic pain or skeletal abnormalities.
Diagnosis
Many of the people with Hereditary Alpha tryptasemia are not diagnosed due to lack of symptoms. Diagnosis is done by genetic testing.
Treatment
Most people with HaT will not require any treatment. Omalizumab and antihistamines may help for those who experience symptoms.
☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.
Learn more about our editorial process for content accuracy.
Source of Information - We analyze big data of more than 23 million patients de-identified medical records from the following sources:
.png)
Find people who are
experiencing a similar
medical reality
Free
Alike Wisdom
Instantly get answers to medical questions with our AI, built from the collective wisdom of our community facing similar experiences
You might also like