What is it?

Gray matter heterotopia refers to a group of neurological conditions caused by nodules of neurons that are mislocated. These nodules cause the brain to malfunction, sometimes resulting in epilepsy or recurring seizures. Not everyone have symptoms, and many times these findings are found incidentally. Symptoms do not tend to get any worse. It is usually an isolated anomaly but may accompany chromosomal abnormalities.

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Signs & symptoms

Symptoms are not found in everyone, but may include recurrent seizures, epilepsy, hypotonia, loss of motor skill and mental retardation.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include a brain MRI, usually done as a result of seizures resistant to medications.


Treatment may be symptomatic. There are several reports of patients who benefit from surgical procedures.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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