What is it?

Cryoglobulinemia are proteins that bind together in temperatures lower than 98.6 F (or 37C) and clump in the blood circulation. This may cause damage to the skin, joints, nerves, kidneys and liver. Cryoglobulinemia has been linked to infections, cancers, lupus, rheumatoid arthritis, and Sjorgen’s syndrome.

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Signs & symptoms

Symptoms may include skin lesions, typically on the legs, joint pain, numbness, tingling and loss of sensations in the fingers and toes.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation includes blood tests.


Treatment depends on the underlying cause and may include immunosuppressive medications, and plasma exchange.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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