What is it?

Penile carcinoma in situ is (CIS) the earliest stage of squamous cell cancer of the penis. In this early stage, the abnormal cells are found only in the outermost layer and have not yet invaded the deeper layers. If CIS is in the glans of the penis, it could also be known as erythroplasia of Queyrat and if it’s on the shaft of the penis it is called Bowen’s disease. From this stage, the disease can progress to invasive carcinoma, if left untreated. penile CIS is seen more in men who had nto been circumsices, and it is linked to HPV infection. Other risk factors include smoking, chronic skin disease such as lichen sclerosus, immune suppression and chronic irritation of the penile area.