What is it?

Penile carcinoma in situ is (CIS) the earliest stage of squamous cell cancer of the penis. In this early stage, the abnormal cells are found only in the outermost layer and have not yet invaded the deeper layers. If CIS is in the glans of the penis, it could also be known as erythroplasia of Queyrat and if it’s on the shaft of the penis it is called Bowen’s disease. From this stage, the disease can progress to invasive carcinoma, if left untreated. penile CIS is seen more in men who had nto been circumsices, and it is linked to HPV infection. Other risk factors include smoking, chronic skin disease such as lichen sclerosus, immune suppression and chronic irritation of the penile area.

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Carcinoma in situ of Penis.

Additional names

This group contains additional names:
- Cancer in situ of penis
- Bowen's disease of penis
- Queyrat's erythroplasia

Signs & symptoms

Symptoms of penile CIS may inlcude rash and irritation of the skin of the penis, itching, crusting or scaling of the lesions, pain, ulcers, bleeding and at later stages discharge, diffulty urination or difficulty pulling back foreskin.


Penile CIS is diagnosed on physical exmination followed by a biopsy.


Treament of penile CIS may include skin creams such as imiquimod or 5-fluorouracil. Other treatments include Mohs microsurgery, laser surgery, cryotherapy, curettage and electrodesiccation.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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