What is it?

Bullous pemphigoid is a rare skin condition that causes large, fluid-filled blisters. They develop on areas of skin that often flex- such as the lower abdomen, upper thighs or armpits. Bullous pemphigoid is most common in older adults.
Bullous pemphigoid occurs when the immune system attacks a thin layer of tissue below the outer layer of skin. The reason for this abnormal immune response is unknown, although it sometimes can be triggered by taking certain medications.

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Signs & symptoms

The signs and symptoms of bullous pemphigoid may include:
* Itching skin, weeks or months before blisters form
* Large blisters that don't easily rupture when touched, often along creases or folds in the skin
* Skin around the blisters that is normal, reddish or darker than normal
* Eczema or a hive-like rash
* Small blisters or sores in the mouth or other mucous membranes (benign mucous membrane pemphigoid)


To confirm the diagnosis, the doctor may order blood tests and take a small sample of the affected skin (skin biopsy) for laboratory testing.
the doctor may refer to a dermatologist or ophthalmologist, depending on the signs and symptoms and the results of the lab tests.


Treatment is focused on healing the skin and relieving itching, while minimizing adverse side effects of medications. the doctor will likely prescribe one or a combination of the drugs:
* Corticosteroids
* Steroid-sparing drugs
* Other drugs that fight inflammation. An example is methotrexate.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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