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Autoinflammatory syndromes
Autoinflammatory syndromes
by Alike Medical Team ∙ Updated on June 13, 2023
Additional names
This group contains additional names: - PFAPA
General
PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis) is a rheumatological condition that appears in children. It is seen in both girls and boys and is typically diagnosed in children between the ages 2-and 5. As its name suggests, it causes repeated episodes of fever, mouth sores, sore throat, and swollen lymph nodes. Rarely, it develops in adulthood. It is yet unknown what causes the activated immune system in PFAPA.
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Signs & symptoms
Symptoms include periodic fever, mouth sores, sore throat, enlarged lymph nodes, white patches on the tonsils, and more rarely- headache, joint pain,abdominal pain, nausea, vomiting and diarrhea. The episodes last between a few days to a week, between the episodes these children are healthy.
Diagnosis
Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include blood tests, and to rule out other conditions strep culture, imaging test and genetic testing may be done.
Treatment
Treatment may include a short course of steroids, colchicine, and sometimes surgery to remove the tonsils.
Note
☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.
National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention
☝ All information has been reviewed by certified physicians from Alike
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