Acquired coagulation factor deficiency
What is it?
Factor VII is a protein produced by the liver and is one of the clotting factors. Factor VII deficiency is a blood clotting disorder that causes excessive or prolonged bleeding. When a blood vessel is damaged, factor VII constricts the blood vessels to slow down blood supply, has a part in the formation of a temporary plug in the wound, formation of fibrin plug and wound healing. Factor VII deficiency may be inherited (rare) or acquired, occurring after birth, due to medication use, and medical conditions such as liver disease, myeloma, sepsis, aplastic anemia or vitamin K deficiency.
Factor X Deficiency is a rare bleeding disorder, which varies in its severity. In its acquired form it may be caused due to other disorders such as liver disease or amyloidosis. Symptoms may appear at any age.
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Acquired coagulation factor deficiency.
Additional names
This group contains additional names:
- Factor VII Deficiency
- Factor X Deficiency
Signs & symptoms
Symptoms may include easy bruising, bleeding from tissues like the gums, nosebleeds, heavy menstrual bleeding, bleeding in joints, and longer bleeding time from wounds.
Diagnosis
Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include factor assays, prothrombin time, and partial prothrombin time as well as a genetic exam.
Treatment
Treatment includes medications to control bleeding such as human prothrombin complex, cryoprecipitate, fresh frozen plasma and recombinant human factor VIIa. Treating the underlying cause is also needed.
☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.
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