What is it?

Zollinger-Ellison syndrome is a rare condition in which gastrinomas, which are a kind of tumor, develop in the pancreas. These tumors release the hormone gastrin, causing the stomach to produce excess acid that leads to peptic ulcers. Typically, Zollinger- Ellison syndrome affects people between the age 20 to 60. Zollinger-Ellison syndrome may be caused by an inherited condition called multiple endocrine neoplasia, type 1 (MEN 1).

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Abnormality of secretion of gastrin.

Additional names

This group contains additional names:
- Zollinger-Ellison syndrome

Signs & symptoms

Symptoms may include abdominal pain, diarrhea, burning and aching in the upper abdomen, acid reflux, nausea, vomiting, bleeding in the digestive tract, weight loss, and decreased appetite.


Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include blood tests for gastrin levels, upper gastrointestinal endoscopy, ultrasound, and other imaging tests.


Treatment includes surgical procedures to remove the gastrinomas , embolization, injecting drugs to the tumors, chemotherapy, and medication to decrease acid production ro relieve the symptoms.

☝️ This is not a substitute for professional medical advice. Please consult with your physician before making any medical decision.

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