Prioritizing Myself: A Guilt Trip of Emotions

Does anyone ever have moments when they know that something is going to affect your plans? but you're prepared for it? like, you have this gut feeling that something unexpected is going to occur and at all cost, you take care of your responsibilities even if it means telling someone no, not treating yourself, or anything else. I felt bad for telling someone no, I know they need my help but if I would have helped them, I would have been pushed between a rock and the ground because I just got hit with something of my own. I don't like telling them no especially knowing what situation they're in, but I have been trying to look after myself lately and it's been a wild guilt trip of multiple emotions and most definitely ANXIETY 😓🙃