Taking high doses of Vyvanse and Wellbutrin together

thank you guys! i didn't even consider mania. i have bipolar 2 and struggle a lot more with depression than hypomania, but i have a few tell-tale signs that i'm going hypomanic that i'll keep an eye out for. i've also been on 300 mg of wellbutrin for 4 years and had been on 60 of vyvanse so it wasn't a huge leap. i took them for the first time today and felt great, so hopefully it stays that way. more than anything i was worried about physical side effects, but that doesn't seem to be a problem so far.

I agree with the above. If you're bipolar it could definitely trigger a manic episode. With that said, I have taken those two high doses and have been fine. Though I am like a horse when it comes to meds, it takes a lot to bring me down. Tread lightly and monitor your symptoms! Good luck!

sounds like a recipe for mania... At least for me!!! (Wellbutrin made me incredibly manic even at 100-150mg over time... I take Vyvanse now 50mg and even with that I need to be conscientious about taking breaks from it regularly so I don't get hypomanic and crasg

I was on 450 Wellbutrin but only 50 of Vyvanse... I was fine for what that's worth. 🤷‍♀️