Hello, 30yo M, diagnosed Asperger Syndrome. I have this feeling often, although I've learned some mannerisms and slightly read faces I still miss tonality and sarcasm; It can leave you feeling embarrassed or left out, or you may feel like you've overstepped. A lot of times, we apply an archetype to people and then use that to heuristically react to their interactions with us. Then, when they change it up or have an 'off day', it can be hard to adapt to seeing them differently. Just know that this is okay. Interpersonal relationships are a complex system, but you don't have to get it right all the time. :) It will even out.