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mynewfriend

815d

Any thoughts about Vraylar? I'm having mixed mania after a few months on Lexapro -not unexpected, it was a shot in the dark- so I'm switching to Vraylar. My lithium will stay the same. I struggle with side effects and couldn't tolerate Latuda or Seroquel most recently. I've struggled most with depression since coming off Lamictal in September. Any thoughts? Warnings? Endearing tales from your epic journey with antipsychotics? FYI: Diagnosed Bipolar type I (I've had full mania), but I tend to present as Bipolar type 2 (long depressions+hypomania)

Top reply
    • mikl_pls

      815d

      I'm very similar to you in that regard (BP 1 with a history of full mania but present mostly as BP2 with long depression and rarely hypomania). I'm actually on Vraylar right now (I think now for the 3rd time). I'm on 1.5 mg which is the recommended dose for depression (max 3 mg, higher doses generally for mania). I like it. Its side effects are pretty benign. No weight gain. Akathisia is pretty common at first so watch out for intense restlessness (your doc can prescribe you something like Cogentin or Artane to help with that if it happens). The first time i took it i did have some rather annoying RLS-like symptoms at night. It takes a VERY long time to build up in your system because it has such a long half life, so it's good that you're already on something like lithium to keep you stable. Endearing tales huh? 😂 I'll say that I've been on just about every atypical antipsychotic except a few and many of the first generation antipsychotics. Of these, I've found that the best ones for my mood (primarily depressed) are Caplyta, Stelazine (an oldie but a goodie), Abilify (which unfortunately causes compulsive spending behavior in me and caused me to rack up over $12,000 in credit card debt), and Vraylar (in that order starting with the best first). Caplyta actually got me out of the deepest rut of my life when i was in horrible circumstances at home during the lockdown of COVID and got me working again. I'm kind of thinking about going back on it if I get depressed again after the ketamine infusions I'm doing right now (have my last infusion next week). So if Vraylar doesn't work for you, I would definitely recommend giving Caplyta a try.

    • mikl_pls

      815d

      I'm very similar to you in that regard (BP 1 with a history of full mania but present mostly as BP2 with long depression and rarely hypomania). I'm actually on Vraylar right now (I think now for the 3rd time). I'm on 1.5 mg which is the recommended dose for depression (max 3 mg, higher doses generally for mania). I like it. Its side effects are pretty benign. No weight gain. Akathisia is pretty common at first so watch out for intense restlessness (your doc can prescribe you something like Cogentin or Artane to help with that if it happens). The first time i took it i did have some rather annoying RLS-like symptoms at night. It takes a VERY long time to build up in your system because it has such a long half life, so it's good that you're already on something like lithium to keep you stable. Endearing tales huh? 😂 I'll say that I've been on just about every atypical antipsychotic except a few and many of the first generation antipsychotics. Of these, I've found that the best ones for my mood (primarily depressed) are Caplyta, Stelazine (an oldie but a goodie), Abilify (which unfortunately causes compulsive spending behavior in me and caused me to rack up over $12,000 in credit card debt), and Vraylar (in that order starting with the best first). Caplyta actually got me out of the deepest rut of my life when i was in horrible circumstances at home during the lockdown of COVID and got me working again. I'm kind of thinking about going back on it if I get depressed again after the ketamine infusions I'm doing right now (have my last infusion next week). So if Vraylar doesn't work for you, I would definitely recommend giving Caplyta a try.

      • mynewfriend

        815d

        @mikl_pls A kindred spirit! Hurray! Caplyta is next on the list, insurance dictated I try this first. The abilify didn't do great for me the last time I took it but that was over a decade ago. Latuda caused really bad akathisia and tyke... the repetitive tongue and limb movement...for several weeks. At the time, the drugs you mentioned to counter act that would have interfered with the beta blocker I took for migraines but I'm not on that now. It's what I'm most worried about with Vraylar. I was bordering on psychotic and suicidal from the akathisia, though the Latuda was helping the depression. Seroquel kept me mostly unconscious for weeks. I'm hoping Vraylar does neither and that I don't have significant weight gain because with my blood pressure, that would be a deal breaker. I appreciate your input

        • mikl_pls

          815d

          @mynewfriend By tyke do you mean TD (tardive dyskinesia)? That's pretty serious! They use beta blockers for akathisia too, but i personally find them useless for akathisia. Benzos too but same. Ineffective. The anticholinergics are the only thing that help me. I didn't know they interacted with beta blockers for migraine. Omg akathisia is one of the worst things ever. People don't understand it until they've experienced it. Seroquel is an antihistamine before it is an antipsychotic. It's very very low potency and i honestly don't see why they use it. I guess if you're so sedated and tranquilized you can't be manic or psychotic! Lol. Good luck with it! (For the record i lost weight with Caplyta but gained it back, not sure if it was the med or what, but that's my experience.)

☝ This content is generated by our users and it is not a substitute for professional medical advice. Please consult with your physician before making any medical decision

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