Have you tried extended release metformin (Metformin XR)? I was having similar problems until I switched. I'm also taking weekly Ozempic7 injections, which helps diabetics manage their blood sugar and reduces their appetite to help lose weight. It's been effective for me so far, but there are definitely rough side effects for the first 1-2 weeks as your body gets used to it (vomiting, gas, diarrhea). Avoiding fatty foods and eating only simple things like chicken noodle soup or applesauce really helps with the transition. Is your thyroid condition still under control even though you cut back on your meds? Thyroid problems make it extra hard to lose weight. I'm sure your doctors have talked your ear off about diet and exercise. I'll just say, specifically I was told that building a bit of lean muscle through strength training can really help your body's metabolism. Are you talking to an endocrinologist or a reproductive endocrinologist? They can be helpful in regards to hormonal conditions such as diabetes and PCOS. Best of luck my friend. Solidarity with your struggles. I'm open to direct messaging you have any specific questions.

I see. Do your doctors believe your inability to conceive is tied to your weight exacerbating your PCOS? Or are they concern about more general health/insulin resistance before trying to conceive?

A little of both. It's more the weight aspect, but despite me being fairly heavy, both my endo and gyno are supportive of me getting pregnant. However, my endo was concerned about me being on anything but metformin because of the dangers posed to the child if I conceive.

https://thepcosnutritionist.com/thepcosprotocol/ Recommend this program for treatment of PCOS. You need a specialist for effective treatment. GPs don’t have the right tools for us.