I never tried a cortisol blocker but I was put on metformin as my first type of treatment for PCOS. It did take a while but it did help my body begin to regulate my hormones and help my insulin resistance! Plus, I lost about 30 pounds!

I haven't tried anything like that but I'm really curious about which medications you're talking about- would you mind sharing their names? The closest thing I can think of is metformin which a lot of people with PCOS have found helpful. The only meds I've been on are psychiatric (which does help with premenstrual distress) & spironolactone which blocks testosterone (it was really problematic for me personally possibly because of its diuretic property affecting my blood pressure but is great for some).

metformin isn’t very new it’s just used off-label to treat pcos. not very experimental since they don’t understand pcos very well. i’ve been taking metformin and birth control and it has regulated my period

I can't say I've tried something anything similar, but I take inositol for my PCOS. It's helped a lot with it.

So what do you mean when you say it helps? Helps what exactly?