I've been on midodrine for 4 years now and it's helped me immensely! It lets me function for longer periods of time with less flaring. I know some people get intolerable side effects but I didn't have any that I noticed aside from maybe some chest tightness. Started out at 2.5mg three times a day but wasn't feeling much of an effect so I got bumped to 5mg then eventually 7.5mg. That's where I was until recently when my doctor decided it was making my BP too high, so now I'm back down to 2.5mg and it's not very effective, like before. Now am trying some 1 gram salt tablets 3 times a day along with it to see if that helps. Your other meds might allow you to keep a lower dose if you can tolerate it I've read some other people say it eventually became less effective or needed to be lowered due to BP concerns like with me. I think it's worth trying, though, because a lot of us POTsie type folks have had success with it. And like tallgirl said it's short acting so very easy to stop if side effects persist after a few weeks of taking it