Options for Medication Resistant Major Depressive Disorder

Effexor is really the only thing that worked to stop my depression from being overwhelming. I really struggle with finding other ways to treat it other than doing therapy weekly which of course also helps but I find that my depression gets very overwhelming if I don’t have the extra help from medicine. I know you mentioned medication wasn’t really working for you so I hope others may have more ideas! I would just make sure to have a good therapist to work with because that’s the only thing I’ve known to be useful

Ability and effexor has helped me

Done everything available. Next step, esketamine.

They tested me for bipolar and cyclothymia, but it's just MDD caused by cPTSD. I'm on 5 diff meds. I'm the best I've ever been, but still have a hard time getting out of bed in the morning if I don't have to. I want to wake up and look forward to starting my day. I want to find things I look forward to, but I'd rather just lay in bed. I will say I no longer cry all the time or have suicidal thoughts. Def a plus!

I have bipolar depression as well. Ziprasidone is what's working for me. It also helps me sleep sometimes, so I take two 40mg pills at night.

Lithium helped me with my bipolar depression. It's not as great as I'd like it to be but it's better than having suicidal thoughts every day

I got diagnosed with bipolar depression. Do you have episodes? Like where you are suicidal? I just started vraylar. I hope it helps im so tired. I also realized that im beating myself up in my mind all day and putting myself down. Im trying to stop but thats a hard habit to break

Ugh I’m in this same boat!