Frustrated with Medication Side Effects and Chronic Illness Symptoms

Does anyone else get frustrated when they try a new medication because their symptoms are also side effects of the medication? Am I dizzy because of my POTS or the new meds? Am I getting cysts because of my birth control.. or my pcos? Is this an allergic reaction or my inflammatory disease? Things like that.. its so frustrating to not be able to tell if my chronic conditions are flaring up or if I'm actually having a side effect when starting a new medication, especially when you have more than one chronic illness so you cover almost every possible symptom of side effects on the medication chart. Does anyone else feel like this?