Different Alters Reacting Differently to Substances - Possible?

CW Drugs // So this is a VERY stupid question, but bear with me. Is it possible for different alters to react to substances differently? Usually whenever we take a few cannabis-infused gummies, we're unaffected for like an hour before it hits us and we get loopy and tired, then just fall asleep. Usually it's me, R (the host) doing this, and usually it's pretty nice since we struggle to fall asleep usually. The other night though, H took a few gummies, and we had just an absolutely god awful trip from Hell. Hallucinating, convulsions, throwing up, anxiety, etc. I know weed does different things sometimes, but to my knowledge, nothing changed about the "routine" except the fact the gummies were a bit older and left out? AFAIK there's a very slim chance they were laced (I'm not discrediting that idea yet, though) The only major difference was who was in front. H already has a few physical differences, like having worsened vertigo. I just don't know if him being in front could have caused such a bad trip? Can some alters handle their weed worse than others??? Preemptively, we've (lovingly) banned him from doing weed again