@Kaori you may need to add something to it. It took a long time for me to figure it out but I think I finally have, a thyroid pill, and Bupropion+ Straterra for energy, mood, attention, focus. My therapist tells me that Straterra has helped two of her other patients that are taking another med in conjunction. It's frustrating that we can't have it all in one med, but I gotta say, I think you should try perhaps adding Straterra to your Zoloft. Obviously you should talk to your doctor about it. I had terrible, terrible fatigue. The Bupropion was actually what gave me the most energy, so that may be the best fit for you... But one of the two patients I mentioned was also on Zoloft so that's why I made that suggestion.