Struggling with Bipolar Disorder and Medication Resistance

I have bipolar type 1 , I was diagnosed the week of my 18th birthday, however i've had different therapists and psych doctors tell my family I had bipolar 1 since i was 5 years old due to the behaviors i was exhibiting at the time, however, i am also diagnosed with Borderline, ADHD and an extreme hormone imbalance, i've been on so many different medications that have no lessened a single symptom , is it possible to be medication resistant due to multiple other disorders working against the medications ? or medication resistant as a whole? if so how can i get helps if meds don't work?