yeah they don’t work for me

That is really strange I feel like they work for me but they make me incredibly sick which makes no sense to me because I took them for a lot of years and even ones that I took for years make me really sick nowadays

SSRIs and SNRIs (like Cymbalta) aren't for everyone. Cymbalta gave me horrible nightmares so I got off of it pretty quickly. Most SSRIs I took had the side effect of weight gain. I was also on Clomapramine for a while, which is a tricyclic antidepressant (different class of medications), and I had really bad orthostatic hypotension (meaning when I stood up from a sitting/lying down position, my blood pressure would drop so low my vision would black out and I actually fell on one occasion). I'm currently on no antidepressant medication--instead I'm taking 2mg of Abilify, a medication called Naltrexone for my Skin Picking Disorder, and stimulant medication for my ADHD. The right choice for me was to get off of antidepressant medication, but that's not a decision to be taken lightly. It's worth asking about a different medication, or a different class of medications, as psychiatric medications are kind of trial-and-error until you find one that does what its supposed to and doesn't have unfortunate side effects.

My mom has a gene that makes her unable to metabolize SSRI's which she passed on to me. They make her manic, but I don't remember what side effects I had from it.

Hmmm ok well thanks guys! I appreciate it. I'm not sure why this happens to me.

SSRI meds don't work for me at all. Have had luck with the SNRI called effexor or venlafaxine. I'm bipolar and also need a mood stabilizer (lamotrigine/lamictal) and antipsychotic (aripiprazole/abilify) though. I do have nausea meds on hand because I take so many medications for a variety of chronic health issues. Not sure if zofran/odansetron would be helpful for you too. I'm so sorry that you're experiencing all those side effects, sounds very unpleasant!