I have AS and don’t have the gene I think about 10% with it don’t have the gene

The HLA B27 is not the only test in the diagnostic process. This gene doesn’t confirm or deny that you have AS it just helps them put the puzzle together on what you do have. I highly suggest you start seeing other doctors in Rheumatology your allowed to and see as many as it takes to get the right diagnosis. You know yourself best so become your best advocate. I will tell you this at my last visit I asked the Rheumatologist is AS genetic ? She said yes! So you do your own math. I also have fibromyalgia. And my daughter at 22 was just diagnosed with both too. (Genetics) There can also be a diagnosis of Axial spondyloarthritis it’s an umbrella term and it includes: Ankylosing Spondylitis (AS) Where changes to the sacroiliac joints or the spine can be seen on x-ray. I hope this helps a bit message me if you have any other questions.

I dont have the gene but i did get the AS diagnosis i get alot of muscle/joint pain but its all day for me too. I would definitely recommend getting a second opinion, xrays of my lower back were what solidified my diagnosis for my doctor. I would ask/push for xrays if you can

I don’t have the gene. I didn’t even learn about the gene until about 2-3 years after my diagnosis. My doctors used blood tests (to see the level of inflammation), X-rays (to see if my spine has any damage…which it certainly does), and MRIs (which showed wedging and bulging of my discs along with some other not her fun things). I also had two doctors look me in my eyes and tell me that there is no chance that I have any form of arthritis… it’s been rough out here

I also dont have the gene but was diagnosed with AS. Keep pushing for answers.