See Alike in...

Alike App

Browser

nerascape

644d

So, I want to get back on an amphetamine stimulant, but unfortunately I am a poor metabolizer of the main enzyme they are broken down by. Methylphenidate I THINK is doing the job, just looses its efficacy kinda quick.

Top reply
    • nerascape

      643d

      @Digipuddi I am on Methylphenidate ER 27mg. Also known as “Concerta”. I had a genetic test done that stated drugs in the methylphenidate family (including dexmethylphenidate) would have moderately reduce efficacy due to my alpha-2 autoreceptor being trigger happy (I am a big pharmacology nerd as you can probably tell). Amphetamines are strong enough to bypass this issue, as they are releasing agents as well as reuptake inhibitors. My liver just can’t break them down well since I am basically missing the main one amphetamines are broken down by. I would either have to have a low dose, or breaks in between so my body has a chance to excrete all of it.

    • PuddingStone

      644d

      I am NOT a doctor but my prescriber has me on an AM and a PM doze of adderal. Maybe that is for you?

      • Digipuddi

        644d

        @PuddingStone I second this! Ive been taking 10mg of adderall XR in the morning for about a year but always felt like I hit a wall in the middle of my day. My psychiatrist recently prescribed a dose of 5mg of instant release adderall to take in the afternoon and it makes my day so much easier to get through. Also, OP are you taking an instant release or extended release methylphenidate? Maybe extended release would help if you’re not already taking it. Definitely talk to your prescriber about this as they would have the most knowledge of what your options are and how things would potentially affect you.

        • nerascape

          643d

          @Digipuddi I am on Methylphenidate ER 27mg. Also known as “Concerta”. I had a genetic test done that stated drugs in the methylphenidate family (including dexmethylphenidate) would have moderately reduce efficacy due to my alpha-2 autoreceptor being trigger happy (I am a big pharmacology nerd as you can probably tell). Amphetamines are strong enough to bypass this issue, as they are releasing agents as well as reuptake inhibitors. My liver just can’t break them down well since I am basically missing the main one amphetamines are broken down by. I would either have to have a low dose, or breaks in between so my body has a chance to excrete all of it.

☝ This content is generated by our users and it is not a substitute for professional medical advice. Please consult with your physician before making any medical decision

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Want to chat or share? Download the Alike app now and get complete access to Alike.health's unique features.

Find people who are
experiencing a similar
medical reality

100% Free
100%
Free

Download Alike for the full experience

JOIN

View All

Bupropion

night sweats

paranoid

Valium

sertraline

palpitations

Anxiety (Including GAD)

Depression

palpitations

Depression

Valium

Bupropion