I too have multiple issues with many medicines. The only time I get off one is to go onto another that isn't compatible. It isn't ideal, but If they work than take as directed. If they aren't than ask for ones that do the same thing that your on. You may have built a tolerance. I did this and lost some of the meds because I had to combine one med to treat 3 things due to side effects if taken with xyz.

Im getting the same thing from my doctors i dont feel like my meds are working