Can Medication Work Again After Stopping?

Im on meloxicam i was on it many years ago but im ready for something else..

Enbrel is the drug I'm on now, and the first real medication I've had. It was working great for the first few years but is now rapidly becoming ineffective.

Hi, I have never tried it because my rheumatologist told me that except for steroids, usually a line of treatment that has been used up will not work again. Have you tried any medicine that worked for you?