Why Does Missing a Day of Depression Medication Make Me Feel Amazing?

This is exactly what happened to me. I have tried so many different antidepressants, and Lexapro/Sertraline had the worst side effects (emotionless, no sex drive, didn't care about anyone or anything, suicidal thoughts). I agree with what everyone is saying here - talk to your provider and see if they can get you on something else. I wish someone would have told me years ago that being "emotionless" wasn't normal. I felt my best when I went off these meds. I'm currently on fluoxetine and Buspirone. I highly recommend taking the Genesight test to see what medication works/doesn't work for you.

I’m not super qualified but what I’ve learned as a neuroscience minor is that setraline or Zoloft is an SSRI selective serotonin reuptake inhibitor serotonin is being pushed into your system at the same time your body that also naturally makes serotonin does something called reuptake or the reabsorption of serotonin into the neurons. The SSRI actually stops this from happening so that more serotonin is available to pass between nearby nerve cells and not just absorbed. When you stop taking it your body is trying to compensate for the missed dose but this means the next day your body is low on serotonin it has gotten used to your med increasing the intake of serotonin so you will feel mood switches if you start on and off. Also starting and stopping is not only bad for mental health but for physical health as well I’m not entirely versed on the effects on the physical body but withdrawal is a sucky symptom to have. I recommend talking to your psych about SSRIs and maybe trying an antidepressant that is not an SSRI if it makes you feel numb or emotionless

It almost sounds a bit like the response people have to antidepressants if they have undiagnosed Bipolar Disorder. Antidepressants can trigger manic episodes, and would likely also be followed by a subsequent depressive episode