Struggling with Isolation: Need Advice

Hello people. I have been struggling with isolation issues for the past two or three years. I live with a roommate who is at college and work while I am also working so we don't get to see each other a lot. I have no family left. I cannot seem to find friends that are as interested in friendship as I am if that makes sense. Nobody around me seems to be interested in a deeper more human connection. I have learned well to deal with loneliness but over the past 4 or 5 months it is starting to gnaw away at me. it's hard to wake up in the morning and want to do anything when you have nobody to share your life with. Just want an outside perspective on how I can tackle this?