ive struggled with severe depression and anxiety and ive also tried almost every ssri with no luck. going along with what Caesar said, i tried Wellbutrin a year or so ago and it was the only medication i've been prescribed that actually seemed to help!! for other reasons i stopped taking it, but i probably shouldnt have. I'm currently self medicating with adderall (as in not prescribed) and its had the best anti-depressant effects on me, more than actual antidepressants. i feel like i can actually function! i dont go home and lay on the floor for hours, i actually have energy after work because it lasts all day. it also practically cures my lack of motivation and my social anxiety as well. im a very shy and reserved person and usually when i try to talk to people, i completely blank out and cant talk. if i take the adderall i can have a normal human conversation🙌 the only thing is like i said i do not have a RX for it and you can easily build a tolerance, so i don't take it every day. sometimes i will still feel the effects of it the next day though! I have found that "uppers" work best for my depression, maybe that's something you could also look into!❤️