Guanfacine and OCD: Is there a connection?

I haven't heard of that but I am not professional. I will say though that both is possible ADHD & OCD. It can also be confused with some similarities like OCD's obsessions and ADHD's hyperfixation. If one has both I personally believe they fuel each other. The more common side effect of guafacine is sedation of sorts as well, I used to take it. I don't have a negative view of it but thought it mellowed my personality (perhaps this is true but I also could have benefited from some therapy addressing social anxiety). One must also be careful going off it, has to be a slow taper off.