I am currently taking 400mg of Wellbutrin SR (which I believe 400mg is the max in a day) and I continue to have overwhelming feelings of sadness, guilt and hopelessness without any reason or explanation. I was on Cymbalta for 7 years and it ruined my life.

Anxiety (Including GAD)




Irritability and Anger




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  • Nightowl


    It's obviously not working for you, you should try something else. I take wellbutrin and it helps me, but it suppresses the sadness but the happiness too. I added Lexapro and feel more like myself. I assume you've been diagnosed with depression; any other health issues or medications that might be negatively affecting the Wellbutrin?

  • Hopeful216


    Hi Nightowl. I take Buspirone for GAD. Adderall for ADD. Armour Thyroid for Hypothyroidism. Naltrexone for weight management. Hydroxyzine as needed for anxiety. Maybe it’s the Adderall? Whenever I see contraindications, it shows that between Adderall, Wellbutrin and Buspirone. I’m extremely afraid to get off of what I am on now because the Cymbalta and Abilify I took for years made me so exhausted and It made other things terrible. Should I inquire to my Psychiatrist during my next appointment about the possibility of adding Lexapro? Thank you very much.

  • Nightowl


    It's concerning that you're on so many different medications. Research their side effects and contraindications. Make sure your doctor knows all your medications and issues, there might be a medication that works for more than one issue or that you could switch out. I would look into that before adding another medication. I was on Strattera for a while for ADD and I had more energy. Therapy might also be helpful.

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